2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel
  5. Calcium Channel Ligand

Calcium Channel Ligand

Calcium Channel Isoform Comparison

Calcium Channel Ligands (4):

Cat. No. Product Name Effect Purity
  • HY-15292
    S107
    		Ligand 99.77%
    S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold.
  • HY-169115A
    (Rac)-PD0299685
    		Ligand
    (Rac)-PD0299685 is a Ca(2+) channel α2δ ligand that was investigated for relieving interstitial cystitis pain in a randomized, double-blind, placebo-controlled phase IIa study. (Rac)-PD0299685 demonstrated a clinically significant reduction in daily worst pain severity scores at the 60 mg dose compared to placebo. (Rac)-PD0299685 is also a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.
  • HY-136644A
    PD-217014
    		Ligand
    PD-217014 is an α2δ ligand with visceral analgesic activity and can inhibit visceral hypersensitivity reactions. Its anti-allodynic effect is dose-dependent.
  • HY-136283
    DMNPE-4 AM-caged-calcium
    		Ligand
    DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca2+ selective cage, with a Kd for Ca2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca2+ (Kd=~2 nM) after photolysis.